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As women enter perimenopause and menopause, declining levels of estrogen, progesterone and testosterone can completely rewrite their metabolic playbook

All these disrupted mechanisms lead to immune dysregulation and LGI, which are part of the hallmarks responsible for the development of CNCDs (Uzunlulu et al., 2016

doi: 10.3389/fendo.2018.00545 102 AversaSPellegrinoSBarberiIReiterRJGittoE

One of the physiological substrates of this transporter is acetylcholine, underlying a key role in the non-neuronal cholinergic system in both physiological and pathological conditions, as testified by the occurrence of a natural mutation of OCTN1 in inflammatory conditions such as Crohns Disease (Pochini et al., 2019)

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